The Cambridge Probiotic/Antibiotic Trial 1
1. Total numbers of the facultative anaerobes:
– significantly increased in the patients on antibiotics and placebo at the end of the antibiotic treatment (*P<0.05) and remained increased post antibiotic therapy (*P<0.05) (Group 1)
– significantly increased in the patients on antibiotics and placebo at the end of the antibiotic treatment (*P<0.05), but the numbers decreased significantly after introducing Lab4 probiotic supplementation post antibiotic (**P<0.05) (Group 2)
– remained stable in the patients on antibiotics and Lab4 probiotics throughout the study period (Group 3)
2. Lab4 supplementation reduced the overgrowth population of coliforms, enterococci and staphylococci in the re-growth microbiota following antibiotic therapy.
Total number of ‘undesirable’ facultative anaerobes
Post antibiotic therapy: Total number of faecal coliforms, enterococci and staphylococci (%)
The supplementation of Lab4 probiotics alongside antibiotic therapy has been shown to reduce the overgrowth of undesirable and potentially harmful bacteria both during and following antibiotic therapy.
Madden JAJ et al 2005. Effects of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: A double-blind, placebo-controlled pilot study.
Int Immunopharmacology 5:1091-1097