This review assessed the efficacy of probiotics, prebiotics or synbiotics in the management of non-alcoholic fatty liver disease (NAFLD). A total of 1309 patients with NAFLD from 25 studies (11 probiotic, 9 prebiotic and 7 synbiotic) were included in the meta-analysis.
All three treatments combined significantly reduced BMI (-0.37 kg/m2), hepatic alanine aminotransferase (−6.9 U/L), aspartate aminotransferase (−4.6 U/L) and gamma-glutamyltransferase (−7.9 U/L), serum cholesterol (-10.1 mg/dl), LDL-cholesterol (-4.5 mg/dl) and TAG (-10.1 mg/dl).
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References: Loman et al. Prebiotic and probiotic treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis. Nutrition Reviews 2018; doi: 10.1093/nutrit/nuy031.